Determination of protein oxidation by mass spectrometry and method transfer to quality control.

作者: Damian Houde , Paivi Kauppinen , Rohin Mhatre , Yelena Lyubarskaya

DOI: 10.1016/J.CHROMA.2006.04.046

关键词: ReproducibilityPeptideHigh-performance liquid chromatographyChemistryChromatographyAnalytical chemistryLiquid chromatography–mass spectrometryMass spectrometryReversed-phase chromatographyProtein oxidationQuantitative analysis (chemistry)

摘要: … to oxidation methionine residues in monoclonal antibodies and recombinant proteins. A method for the determination of oxidation … for determination of protein oxidation (data not shown). …

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