Guidelines on Antibiotic Combination in ICU Patients

摘要: Nosocomial infections are ubiquitous and Intensive Care Units (ICUs) probably the most important focus of nosocomial in a hospital [1]. ICUs were described 1971 by hygiene offiicer as Mecca microbes [2]. Today this statement can be considered even more appropriate considering that, although only 5-10% all hospitalized patients treated ICUs, they account for approximately 25% infections, that incidence is 5-10 times higher than observed general wards [3]. Moreover, frequently reservoirs highly resistant virulent microrganisms [4]. Some major risk factors infection have been identified [5] may explain situation. In fact, normal host defence mechanisms critically ill often impaired use devices (i.e. intravascular devices, endotracheal tubes, urinary catheterization) to discontinued soon possible order reduce infections. Furthermore, normally low pH stomach neutralized H2-blockers or antiacids, promoting growth enteric [6].