Disaccharidase deficiency in pediatric patients with celiac disease and intact villi
作者： Richard L. Mones , Abena Yankah , Diane Duelfer , Rami Bustami , Geraldine Mercer
DOI: 10.3109/00365521.2011.619276
关键词: Lactase 、 Case-control study 、 Pathology 、 Duodenum 、 Intestinal mucosa 、 Biopsy 、 Disaccharidase 、 Gastroenterology 、 Maltase 、 Internal medicine 、 Sucrase 、 Biology
摘要: Background and aims. The “gold standard” for the diagnosis of celiac disease (CD) is the small intestinal biopsy. A significant number of biopsies are inadequate for interpretation. Furthermore, the labeling of a biopsy as a Marsh I or II is somewhat subjective and may vary with the experience of the pathologist. Our hypothesis is that patients with intact villi undergoing biopsies frequently have associated disaccharidase deficiencies (DSD). Methods. We reviewed 220 charts of pediatric patients with CD and selected those with a …
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