Sudden infant death and maternal cigarette smoking: results from the Lower Saxony Perinatal Working Group.

摘要: Maternal smoking has long been identified as a risk factor for sudden infant death (SID). However, only few studies analysed the biological plausibility of relationship between maternal and SID. In Lower Saxony (North Germany), detailed information concerning perinatal period is routinely obtained almost all infants born in this region. The data sets from 190 SID cases who had died 1986 1990 whom full autopsy performed were compared to 5920 random controls, frequency matched on year birth. After adjusting potential confounders (socio-economic status, birth weight, age nationality), during pregnancy was still associated with significantly increased (odds ratio (OR) 2.7, 95% confidence interval (CI) 1.7–4.5). There clear dose-effect number cigarettes smoked SID: adjusted ORs 2.6 (1.5–4.4) 1–10 cigarettes/day, 2.8 (1.8–6.0) 11–20 6.9 (1.9–25.5) >20 cigarettes/day. also appeared be an interaction anaemia: doubled if mothers not smoked, but anaemic (haemoglobin <100 g/l). These results support concept that direct effects fetus which are later life. exact mechanism(s) whereby increases SID, however, remains determined. detrimental should strongly addressed any national or local campaign aiming reduce incidence community.