Nogo-B promotes the epithelial-mesenchymal transition in HeLa cervical cancer cells via Fibulin-5
作者： WEI XIAO , SHUMIN ZHOU , HUA XU , HENG LI , GUOQING HE
DOI: 10.3892/OR.2012.2069
关键词: Cell adhesion 、 Cell biology 、 Cell migration 、 HeLa 、 Cancer 、 Metastasis 、 Cell 、 Carcinogenesis 、 Epithelial–mesenchymal transition 、 Biology
摘要: Cervical cancer is a common malignancy in women worldwide, and the occurrence of invasion metastasis major cause for most cancer-related deaths. Epithelial-mesenchymal transition (EMT) has been implicated primary tumors provides molecular mechanisms cervical metastasis. We previously reported that Nogo-B mediates cell motility by binding Fibulin-5. Herein, we show increased expression correlated with degree In HeLa cells, overexpression induces EMT promotes migration invasion, while inhibiting adhesion. Furthermore, found accumulates co-localizes Fibulin-5 pseudopods, downstream effects on could be partially abolished RNA interference against These results suggest functions as an inducer this effect mediated, at least part, through
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