Detection of cryptococcal antigen. Comparison of two latex agglutination tests.

摘要: The detection of cryptococcal antigen by means the agglutination antibody-coated latex particles is an important aid in diagnosis cryptococcosis. A commercially available test (IBL kit) was compared with from Center for Disease Control regard to sensitivity, specificity, and height titer. Over a 13-month period, 335 specimens were tested both kits. There one false-positive reaction kits (0.4%) false-negative only CDC kit, among 18 patients who had meningitis or disseminated infection due Cryptococcus neoformans. Sera localized pulmonary cryptococcosis showed negative results titers measured two same within dilutions 22 26 cerebrospinal fluid serum proved Overall, IBL kit favorably serum.