Bacteraemia in hospitalised patients with malignant blood disorders: a retrospective study of causative agents and their resistance profiles during a 14-year period without antibacterial prophylaxis.

摘要: Bacteraemia is a major cause of morbidity and mortality in patients with haematological disorders during chemotherapy-induced neutropenia. The generally reported trend the last two decades has been gradual replacement Gram-negative bacilli by Gram-positive cocci as causes bacteraemia neutropenic hosts. However, data that are unaffected use antibacterial prophylaxis scarce. Our objective therefore was to study incidence different microorganisms haematology centre where not used years 1988–2001. A total 1402 episodes clinically significant 927 were identified. All treated wards had an underlying disorder, lymphoma, leukaemia, myeloma dominating. There 536 (58%) male, 391 (42%) female patients, median age 58 years. dominating pathogens coagulasenegative staphylococci (CNS) 17%, Escherichia coli 16%, alpha-haemolytic streptococci 12%, Staphylococcus aureus 9%, Klebsiella spp Enterococcus 7%, Pseudomonas 5%. only change increase E. faecium bacteraemia. balance between essentially stable over 14year period. rates antibiotic resistance low stable. bacteria exhibited fluoroquinolones after 1998. 7- 30-day 6.3 15.6%, respectively, being significantly higher caused aeruginosa, Stenotrophomonas maltophilia ,o rE. faecium. Hematology Journal (2003) 4, 420–426. doi:10.1038/sj.thj.6200334