Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome
作者： Aliesha L Griffin , Priyadarshini Jaishankar , Jean-Marc Grandjean , Steven H Olson , Adam R Renslo
DOI: 10.1093/BRAINCOMMS/FCZ008
关键词: Clemizole 、 Serotonin 、 5-HT receptor 、 Fenfluramine 、 Drug development 、 Trazodone 、 Receptor 、 Medicine 、 Pharmacology 、 Dravet syndrome
摘要: Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, …
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William A Catterall, Franck Kalume, John C Oakley, None, NaV1.1 channels and epilepsy The Journal of Physiology. ,vol. 588, pp. 1849- 1859 ,(2010) , 10.1113/JPHYSIOL.2010.187484
Andrew Escayg, Alan L. Goldin, Sodium channel SCN1A and epilepsy: Mutations and mechanisms Epilepsia. ,vol. 51, pp. 1650- 1658 ,(2010) , 10.1111/J.1528-1167.2010.02640.X
Jian Kang, Li Jiang, Steven A. Goldman, Maiken Nedergaard, Astrocyte-mediated potentiation of inhibitory synaptic transmission. Nature Neuroscience. ,vol. 1, pp. 683- 692 ,(1998) , 10.1038/3684
Berten Ceulemans, Marc Boel, Katrien Leyssens, Carolin Van Rossem, Pieter Neels, Philippe G. Jorens, Lieven Lagae, Successful use of fenfluramine as an add-on treatment for Dravet syndrome Epilepsia. ,vol. 53, pp. 1131- 1139 ,(2012) , 10.1111/J.1528-1167.2012.03495.X
Paul R. Hartig, John P. Patterson, David W. Robertson, Ilgar Abbaszade, Jeannine M. Hollis, Barry S. Brown, Lawrence W. Fitzgerald, Brian L. Largent, Gregory F. Hollis, Timothy C. Burn, Martha H. Corjay, Jung-Hui Sun, John R. Link, Paul C. Meunier, Patricia A. Valentine, Albert J. Robichaud, Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine. Molecular Pharmacology. ,vol. 57, pp. 75- 81 ,(2000)
Grietje Krabbe, Vitali Matyash, Ulrike Pannasch, Lauren Mamer, Hendrikus W.G.M. Boddeke, Helmut Kettenmann, Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity Brain Behavior and Immunity. ,vol. 26, pp. 419- 428 ,(2012) , 10.1016/J.BBI.2011.12.002
Bryan L. Roth, Drugs and valvular heart disease. The New England Journal of Medicine. ,vol. 356, pp. 6- 9 ,(2007) , 10.1056/NEJMP068265
Yingxue Wang, Sandro Romani, Brian Lustig, Anthony Leonardo, Eva Pastalkova, Theta sequences are essential for internally generated hippocampal firing fields. Nature Neuroscience. ,vol. 18, pp. 282- 288 ,(2015) , 10.1038/NN.3904
Marion Kilian, H.-H. Frey, Central monoamines and convulsive thresholds in mice and rats Neuropharmacology. ,vol. 12, pp. 681- 692 ,(1973) , 10.1016/0028-3908(73)90121-4
Richard B. Rothman, Michael H. Baumann, Jason E. Savage, Laura Rauser, Ace McBride, Sandra J. Hufeisen, Bryan L. Roth, Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. ,vol. 102, pp. 2836- 2841 ,(2000) , 10.1161/01.CIR.102.23.2836