Identification of Novel Deregulated RNA Metabolism-Related Genes in Non-Small Cell Lung Cancer

摘要: Lung cancer is a leading cause of death worldwide. Several alterations in RNA metabolism have been found lung cells; this suggests that metabolism-related molecules are involved the development pathology. In study, we searched for genes exhibit different expression levels between normal and tumor tissues. We identified eight differentially expressed adenocarcinoma microarray datasets. Of these, seven were up-regulated whereas one was down-regulated. Interestingly, most these had not previously associated with cancer. These play diverse roles mRNA metabolism: three spliceosome (ASCL3L1, SNRPB SNRPE), others participate RNA-related processes such as translation (MARS MRPL3), stability (PCBPC1), transport (RAE), or editing (ADAR2, also known ADARB1). Moreover, high incidence loss heterozygosity at chromosome 21q22.3, where ADAR2 locus located, NSCLC cell lines primary tissues, suggesting downregulation specific genetic losses. Finally, series patients, five deregulated MARS, RAE, SNRPE) correlated prognosis. Taken together, results support hypothesis changes pathogenesis cancer, identify new potential targets treatment disease.