Latent Tuberculosis: Is There a Role for Thioridazine?

摘要: Approximately 1/3 of the world's population is infected with Mycobacterium tuberculosis. In vast majority cases this results in latent not active disease. Latent disease defined as a positive reaction to tuberculin antigens but without any further clinical symptoms. Models have been developed study tuberculosis two most prominent being vivo murine model and vitro Wayne model. both M. undergoes change its respiratory profile it shifts down nonreplicating state. However mouse model, dormant sensitive phenothiazine thioridazine. This antibiotic has several targets, main one respiration. There growing burden multidrug resistant extensively drug Treatment these expensive high mortality. We propose that thioridazine alone, or other antibiotics, be used treat The advantages are inexpensive, effective against tuberculosis, well characterized unlikely induce resistance. disadvantages include possible side effects, although should rare at doses length time treatment. Recent patents involving analogs suggest class drugs may hold great promise for future treatment strains.