Pituitary dysfunction after aneurysmal subarachnoid hemorrhage is associated with impaired early outcome

摘要: Objective Poor outcome and neuropsychological sequelae after aneurysmal subarachnoid hemorrhage (SAH) is a persistent problem. Pituitary dysfunction has been proposed as contributing factor. Clinical studies have given variable conflicting results on its importance incidence SAH. The aim of this study was to prospectively examine SAH patients with assessment endocrine function in the acute stage at early follow-up compare clinical features abnormalities indicating pituitary dysfunction. Methods Endocrine assessed by basal hormonal concentrations 5 10 days 3 6 months Growth hormone deficiency also evaluated growth releasing hormone–arginine stimulation test follow-up. scored according Glasgow Outcome Scale. Results Fifty-one were included bleed. Six lost overall prevalence 37% 27% follow-up, respectively. Patients evidence had significantly worse Scale both occasions. ruptured aneurysm more commonly located circle Willis among stage. Conclusions present support earlier findings that are not infrequent Furthermore, our data suggest associated common bleeding sites close hypothalamus.