Myocardial release of hypoxanthine and urate during angioplasty

摘要: Oxygen free radicals have been implicated in ageing, oncogenesis and atherogenesis [1], One potential source is xanthine oxidase, the oxyradical-producing form of oxidoreductase. This enzyme catabolizes high-energy-phosphate metabolites hypoxanthine to urate (Fig. 1). Ischemia converts native enzyme, reductase, oxidase [2]. During reperfusion oxygen available for production superoxide hydroxyl [3, 4], both which are strongly suspected cause tissue damage 5–7]. Xanthine oxidoreductase activity present myocardium a number species [8], but its presence human heart controversial. In autopsy material several authors measured high [9, 10]. Using histochemical techniques, Jarasch coworkers found large amounts endothelium [11]. On other hand, reported very low undetectable [12–14]. We evidence that (a of) cardiac patients produces significant urate. Thus may be active vivo.