Protein-Lipid Interactions in Biological Membranes

摘要: The canonical Singer–Nicolson model of lipid bilayers with embedded proteins emphasize the passive barrier properties bilayer component. It is, however, becoming increasingly clear that notion as essentially inert two-dimensional sheets liquid hydrocarbon is problematic. There increasing evidence for regulation integral membrane protein function by molecular composition matrix. In many cases, nonspecific in sense coupled to a physical property such equilibrium thickness and spontaneous monolayer curvature. This can be rationalized considering hydrophobic matching between bilayer. Thus, whenever an membane undergoes conformational change involving its transmembrane moiety, part free energy associated determined chapter first reviews basic structural two main classes proteins: alpha-helical bundles beta-barrels. Then, examples recent advances electron paramagnetic resonance (EPR) nuclear magnetic (NMR) spectroscopy revealing orientational information about fluid are presented. Finally, continuum elastic description protein–lipid interactions presented emphasis on how quantify energetics interactions. Keywords: protein–lipid interaction; fluid-mosaic; Singer–Nicolson model; hydrophobic principle