Activation of the NF-κB pathway by Caspase 8 and its homologs
作者： Preet M Chaudhary , Michael T Eby , Alan Jasmin , Arvind Kumar , Li Liu
关键词: Cell biology 、 Caspase 3 、 Death-inducing signaling complex 、 Caspase 10 、 Caspase 2 、 Caspase 7 、 Caspase 8 、 NLRP1 、 Biology 、 Caspase
摘要: Caspase 8 is the most proximal caspase in cascade and has been known for its role mediation of cell death by various receptors belonging to TNFR family. We have discovered that can activate NF-kappaB pathway independent activity as a pro-apoptotic protease. This property localized N-terminal prodomain, which contains two homologous effector domains (DEDs). 10 MRIT, DEDs-containing homologs 8, similarly pathway. Dominant-negative mutants prodomain block induced FADD several interact with multiple proteins be involved activation pathway, including serine-threonine kinases RIP, NIK, IKK1 IKK2. Thus, caspases homolog(s) may functions beyond their death. Oncogene (2000) 19, 4451 - 4460.
nature.com
elsevier.com
sci-hub.se 参考文章(41)
J A Brockman, D C Scherer, T A McKinsey, S M Hall, X Qi, W Y Lee, D W Ballard, Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation. Molecular and Cellular Biology. ,vol. 15, pp. 2809- 2818 ,(1995) , 10.1128/MCB.15.5.2809
Mark P. Boldin, Eugene E. Varfolomeev, Zeev Pancer, Igor L. Mett, Jacques H. Camonis, David Wallach, A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain Journal of Biological Chemistry. ,vol. 270, pp. 7795- 7798 ,(1995) , 10.1074/JBC.270.14.7795
S Grimm, M K Bauer, P A Baeuerle, K Schulze-Osthoff, Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis. Journal of Cell Biology. ,vol. 134, pp. 13- 23 ,(1996) , 10.1083/JCB.134.1.13
Joseph A. DiDonato, Makio Hayakawa, David M. Rothwarf, Ebrahim Zandi, Michael Karin, A cytokine-responsive IκB kinase that activates the transcription factor NF-κB Nature. ,vol. 388, pp. 548- 554 ,(1997) , 10.1038/41493
Wen-Chen Yeh, Arda Shahinian, Daniel Speiser, Janine Kraunus, Filio Billia, Andrew Wakeham, José Luis de la Pompa, David Ferrick, Betty Hum, Norman Iscove, Pamela Ohashi, Mike Rothe, David V Goeddel, Tak Wah Mak, Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice Immunity. ,vol. 7, pp. 715- 725 ,(1997) , 10.1016/S1074-7613(00)80391-X
H. Nakano, M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, K. Okumura, Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 3537- 3542 ,(1998) , 10.1073/PNAS.95.7.3537
Ebrahim Zandi, David M Rothwarf, Mireille Delhase, Makio Hayakawa, Michael Karin, The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation Cell. ,vol. 91, pp. 243- 252 ,(1997) , 10.1016/S0092-8674(00)80406-7
C. Wang, NF-B Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation Science. ,vol. 281, pp. 1680- 1683 ,(1998) , 10.1126/SCIENCE.281.5383.1680
Preet M Chaudhary, Michael Eby, Alan Jasmin, Angela Bookwalter, Jessica Murray, Leroy Hood, Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway Immunity. ,vol. 7, pp. 821- 830 ,(1997) , 10.1016/S1074-7613(00)80400-8
D. K. M. Han, P. M. Chaudhary, M. E. Wright, C. Friedman, B. J. Trask, R. T. Riedel, D. G. Baskin, S. M. Schwartz, L. Hood, MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 11333- 11338 ,(1997) , 10.1073/PNAS.94.21.11333