Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia.
作者： Ai-Ping Qin , Chun-Feng Liu , Yuan-Yuan Qin , Li-Zhi Hong , Min Xu
关键词: Internal medicine 、 Biology 、 Autophagy 、 LAMP2 、 Glial fibrillary acidic protein 、 Downregulation and upregulation 、 Cathepsin B 、 Endocrinology 、 Astrocyte 、 Hypoxia (medical) 、 Ischemia
摘要: The present study evaluated autophagy activation in astrocytes and its contribution to astrocyte injury induced by cerebral ischemia and hypoxia. Focal cerebral ischemia was induced …
sci-hub.se 参考文章(45)
M Aschner, None, Astrocytic functions and physiological reactions to injury: the potential to induce and/or exacerbate neuronal dysfunction--a forum position paper. Neurotoxicology. ,vol. 19, pp. 7- 38 ,(1998)
X. Zhao, B.R. Pike, J.K. Newcomb, K.K.W. Wang, R.M. Posmantur, R.L. Hayes, Maitotoxin induces calpain but not caspase-3 activation and necrotic cell death in primary septo-hippocampal cultures. Neurochemical Research. ,vol. 24, pp. 371- 382 ,(1999) , 10.1023/A:1020933616351
Yan-Bo Zhang, Sheng-Xing Li, Xi-Ping Chen, Li Yang, Yun-Ge Zhang, Ran Liu, Lu-Yang Tao, Autophagy is activated and might protect neurons from degeneration after traumatic brain injury Neuroscience Bulletin. ,vol. 24, pp. 143- 149 ,(2008) , 10.1007/S12264-008-1108-0
S.S. Mann, J.A. Hammarback, Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. Journal of Biological Chemistry. ,vol. 269, pp. 11492- 11497 ,(1994) , 10.1016/S0021-9258(19)78150-2
A Biederbick, H P Elsässer, H F Kern, Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. European Journal of Cell Biology. ,vol. 66, pp. 3- 14 ,(1995)
E. M. Koehler-Stec, I. A. Simpson, S. J. Vannucci, K. T. Landschulz, W. H. Landschulz, Monocarboxylate transporter expression in mouse brain American Journal of Physiology-endocrinology and Metabolism. ,vol. 275, ,(1998) , 10.1152/AJPENDO.1998.275.3.E516
Zhen Zheng, Jong Youl Kim, Hualong Ma, Jong Eun Lee, Midori A Yenari, Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke Journal of Cerebral Blood Flow and Metabolism. ,vol. 28, pp. 53- 63 ,(2008) , 10.1038/SJ.JCBFM.9600502
R. Schmidt-Kastner, K. Wietasch, H. Weigel, U.T. Eysel, Immunohistochemical staining for glial fibrillary acidic protein (GFAP) after deafferentation or ischemic infarction in rat visual system: features of reactive and damaged astrocytes. International Journal of Developmental Neuroscience. ,vol. 11, pp. 157- 174 ,(1993) , 10.1016/0736-5748(93)90076-P
Yukiko Kabeya, Noboru Mizushima, Takashi Ueno, Akitsugu Yamamoto, Takayoshi Kirisako, Takeshi Noda, Eiki Kominami, Yoshinori Ohsumi, Tamotsu Yoshimori, LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing The EMBO Journal. ,vol. 19, pp. 5720- 5728 ,(2000) , 10.1093/EMBOJ/19.21.5720
Avital Schurr, Ralphiel S. Payne, James J. Miller, Benjamin M. Rigor, Brain Lactate Is an Obligatory Aerobic Energy Substrate for Functional Recovery After Hypoxia: Further In Vitro Validation Journal of Neurochemistry. ,vol. 69, pp. 423- 426 ,(2002) , 10.1046/J.1471-4159.1997.69010423.X