Developmental and cyclic adenosine 3',5'monophosphate-dependent regulation of inhibin subunit messenger ribonucleic acids in human fetal testes.
作者： M Erämaa , K Heikinheimo , R Voutilainen
DOI: 10.1210/JCEM.75.3.1325475
关键词: Protein subunit 、 Fetus 、 In situ hybridization 、 Ovary 、 Biology 、 Messenger RNA 、 Endocrinology 、 Gene expression 、 Testicle 、 Internal medicine 、 Adenosine
摘要: Inhibin subunit messenger ribonucleic acids (mRNAs) are expressed during the gonadal development of rodent, ovine, and bovine fetuses. We investigated expression inhibin mRNAs in human fetal gonads between 13 25 weeks gestational age. In testes, alpha-subunit mRNA was highly at beginning second trimester its level slightly decreased thereafter. Also beta B-subunit detected throughout this time period but no significant developmental change could be observed. Northern analysis showed a 1.6-kilobase (kb) transcript for alpha-chain, as well two bands about 5.0 4.5 kb B-subunit. A Leydig cell tumor also 1.6-kb alpha-subunit. By filter hybridization studies, A-chain not observed testes none three subunits were detectable ovaries stage. However, reverse-transcription polymerase chain reaction revealed expressi...
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