Host proteins that bind to or mimic SV40 large T antigen: using antibodies to look at protein interactions and their significance.
作者： Mole Se , Lane Dp , Gannon Jv , Ford Mj , Anton Ia
DOI:
关键词: SV40 large T antigen 、 Enzyme 、 DNA polymerase 、 Molecular biology 、 Antibody 、 Protein–protein interaction 、 Cell biology 、 Binding site 、 Monoclonal antibody 、 Biology 、 Immunochemistry
摘要: To study cellular proteins which interact with T we chose to use an immunochemical approach initially involved the raising and mapping of monoclonal antibodies bind T. We have successfully exploited some properties these map functional domains The aim this was define interactions two particular host proteins, p53 DNA polymerase α, large explore existence homologues
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