Cold agglutination. Antibodies and antigens

摘要: Abstract Antibodies and antigens of cold autoagglutination are reviewed correlations between agglutinin (CA) structure specificity discussed. Most commonly, CA IgM, but IgG CA, mixed IgG-IgM IgA were also found. In contrast to the heterogeneous postinfectious chronic disease monoclonal κ-type, except for rare cases IgM(λ) CA. Usually react with erythrocyte I/i, several reacting Pr system found more recently. The homogeneity molecules serological chemical differentiation corresponding permitted structural studies on respect specificity, including N-terminal amino acid sequence analyses H- L-chains. Except one anti-Pr 2 , IgM(κ) anti-I/i. Anti-I κ-chains belong predominantly V κII anti-I μ-chains HI . IgA(κ) 1 Anti-Pr H-chains not subgroup κIV is associated specificity.