Acute Myeloid Leukemia in Infants: Biology and Treatment
作者： Riccardo Masetti , Francesca Vendemini , Daniele Zama , Carlotta Biagi , Andrea Pession
关键词: Hematopoietic stem cell transplantation 、 Medicine 、 Age groups 、 Toxicity data 、 Disease 、 Childhood AML 、 Toxicity 、 Pediatrics 、 Myeloid leukemia 、 Treatment results
摘要: Children aged 0–2 years (i.e. infants) with acute myeloid leukemia (AML) are a peculiar subgroup of patients in the childhood AML scenario. They present distinctive biological and clinical characteristics, including high prevalence prognostically unfavorable risk factors an increased susceptibility to therapy-related toxicity. Remarkable improvements have been achieved over last 2 decades treatment these their outcome is becoming superimposable that older age groups. In this review, we will focus on peculiarities young children AML, describing presentation, biology disease influencing outcome. Treatment results toxicity data reported by major collaborative groups also summarized compared.
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