The recent progress of isoxazole in medicinal chemistry.

作者: Jie Zhu , Jun Mo , Hong-zhi Lin , Yao Chen , Hao-peng Sun

DOI: 10.1016/J.BMC.2018.05.013

关键词: Combinatorial chemistryChemistryAnti inflammationIsoxazole

摘要: … isoxazole ring can offer improved physical-chemical properties. Because of the unique profiles, isoxazole … paid to the applications of isoxazole compounds in treating multiple diseases, …

参考文章(74)
Claudio Pisano, Walter Cabri, Riccardo Baruchello, Daniele Simoni, Giuseppina Grisolia, Giuseppina Barbato, Paolo Marchetti, Riccardo Rondanin, Stefania Mangiola, Giuseppe Giannini, Tiziana Brunetti, Domenico Alloatti, Grazia Gallo, Andrea Ciacci, Loredana Vesci, Massimo Castorina, Ferdinando M. Milazzo, Maria L. Cervoni, Mario B. Guglielmi, Marcella Barbarino, Rosanna Foderà, Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90. Journal of Medicinal Chemistry. ,vol. 54, pp. 8592- 8604 ,(2011) , 10.1021/JM201155E
Preet Anand, Baldev Singh, Pyrrolo-isoxazole: a key molecule with diverse biological actions. Mini-reviews in Medicinal Chemistry. ,vol. 14, pp. 623- 627 ,(2014) , 10.2174/1389557514999140728102737
Marcin Mączyński, Jolanta Artym, Maja Kocięba, Iwona Kochanowska, Stanisław Ryng, Michał Zimecki, Anti-inflammatory properties of an isoxazole derivative – MZO-2 Pharmacological Reports. ,vol. 68, pp. 894- 902 ,(2016) , 10.1016/J.PHAREP.2016.04.017
Mahesh A. Barmade, Prashant R. Murumkar, Mayank Kumar Sharma, Mange Ram Yadav, Medicinal Chemistry Perspective of Fused Isoxazole Derivatives. Current Topics in Medicinal Chemistry. ,vol. 16, pp. 2863- 2883 ,(2016) , 10.2174/1568026616666160506145700
Annamaria Martorana, Valentina Giacalone, Riccardo Bonsignore, Andrea Pace, Carla Gentile, Ivana Pibiri, Silvestre Buscemi, Antonino Lauria, Antonio Palumbo Piccionello, Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease. Current Pharmaceutical Design. ,vol. 22, pp. 3971- 3995 ,(2016) , 10.2174/1381612822666160518141650
Raquel C. Montenegro, Peter G.K. Clark, Alison Howarth, Xiao Wan, Alessandro Ceroni, Paulina Siejka, Graciela A. Nunez-Alonso, Octovia Monteiro, Catherine Rogers, Vicki Gamble, Rommel Burbano, Paul E. Brennan, Cynthia Tallant, Daniel Ebner, Oleg Fedorov, Eric O’Neill, Stefan Knapp, Darren Dixon, Susanne Müller, BET inhibition as a new strategy for the treatment of gastric cancer Oncotarget. ,vol. 7, pp. 43997- 44012 ,(2016) , 10.18632/ONCOTARGET.9766
Hanumappa Ananda, Kothanahally S. Sharath Kumar, Mahesh Hegde, Kanchugarakoppal S. Rangappa, Induction of apoptosis and downregulation of ERα in DMBA-induced mammary gland tumors in Sprague–Dawley rats by synthetic 3,5-disubstituted isoxazole derivatives Molecular and Cellular Biochemistry. ,vol. 420, pp. 141- 150 ,(2016) , 10.1007/S11010-016-2777-Z
Chi Zhang, Xin Wang, Hongchun Liu, Minmin Zhang, Meiyu Geng, Liping Sun, Aijun Shen, Ao Zhang, Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors European Journal of Medicinal Chemistry. ,vol. 125, pp. 315- 326 ,(2017) , 10.1016/J.EJMECH.2016.09.043
Wei Shi, Jinglin Hu, Na Bao, Dongang Li, Li Chen, Jianbo Sun, Design, synthesis and cytotoxic activities of scopoletin-isoxazole and scopoletin-pyrazole hybrids Bioorganic & Medicinal Chemistry Letters. ,vol. 27, pp. 147- 151 ,(2017) , 10.1016/J.BMCL.2016.11.089