Core Breast Biopsies Showing Lobular Carcinoma In Situ Should Be Excised and Surveillance Is Reasonable for Atypical Lobular Hyperplasia

作者: Lauren Q. Chang Sen , Wendie A. Berg , Regina J. Hooley , Gloria J. Carter , Mohamed M. Desouki

DOI: 10.2214/AJR.15.15425

关键词: Lobular carcinomaDuctal carcinomaIn situLesionPathologyLobular NeoplasiaPercutaneousMalignancyMedicineBreast biopsy

摘要: OBJECTIVE. The purpose of this article is to determine the upgrade rate ductal carcinoma in situ (DCIS) or invasive at excision same site after percutaneous breast biopsy findings atypical lobular hyperplasia (ALH) (LCIS) using current imaging and strict pathologic criteria. MATERIALS AND METHODS. From January 2006 through September 2013, 32,960 core biopsies were performed; 1084 (3.3%) found ALH classic LCIS. For 447 lesions 433 women, was only high-risk lesion that site, with no ipsilateral malignancy, results available. RESULTS. Among lesions, 22 (4.9%) malignant excision, including 10 carcinomas (two grade 2 eight 1; all node negative) 12 DCIS. LCIS 9.3% (10/108; 95% CI, 5.1–16.2%) 3.5% (12/339; 2.0–6.1%; p = 0.02). After excluding five cases radiologic-pathologic discordance reclassifying one...

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