Optimisation of glutathione conjugation to liposomes quantified with a validated HPLC assay

作者: Joy N. Reginald-Opara , Darren Svirskis , Simon J. O'Carroll , Sreevalsan Sreebhavan , Justin M. Dean

DOI: 10.1016/J.IJPHARM.2019.118451

关键词: Zeta potentialLiposomeConjugateGlutathioneChromatographyDetection limitDrug deliveryTripeptideProton NMRChemistry

摘要: … were added to the DSPE-PEG-mal to achieve the desired GSH:DSPE-PEG-mal molar ratio (… i) GSH-PEG-DSPE conjugation pathway, and ii) 1 H NMR spectra of (a)DSPE-PEG-mal in …

参考文章(38)
Farouk Salem, Sayed M Ahammed, Ashraf S Hassaballah, Mahmoud M Omar, Targeting brain cells with glutathione-modulated nanoliposomes: in vitro and in vivo study. Drug Design Development and Therapy. ,vol. 9, pp. 3705- 3727 ,(2015) , 10.2147/DDDT.S85302
Mansoor Amiji, Srujan Gandham, Meghna Talekar, Amit Singh, Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis. International Journal of Nanomedicine. ,vol. 10, pp. 4405- 4423 ,(2015) , 10.2147/IJN.S82818
Jaap Rip, Linda Chen, Robin Hartman, Angelique van den Heuvel, Arie Reijerkerk, Joan van Kregten, Burt van der Boom, Chantal Appeldoorn, Marco de Boer, David Maussang, Elizabeth C. M. de Lange, Pieter J. Gaillard, Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood–brain barrier in rats Journal of Drug Targeting. ,vol. 22, pp. 460- 467 ,(2014) , 10.3109/1061186X.2014.888070
Marie Gaumet, Angelica Vargas, Robert Gurny, Florence Delie, Nanoparticles for drug delivery: the need for precision in reporting particle size parameters. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 69, pp. 1- 9 ,(2008) , 10.1016/J.EJPB.2007.08.001
Jakob R. Winther, Colin Thorpe, Quantification of Thiols and Disulfides Biochimica et Biophysica Acta. ,vol. 1840, pp. 838- 846 ,(2014) , 10.1016/J.BBAGEN.2013.03.031
Kun Shao, Rongqin Huang, Jianfeng Li, Liang Han, Liya Ye, Jinning Lou, Chen Jiang, Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain. Journal of Controlled Release. ,vol. 147, pp. 118- 126 ,(2010) , 10.1016/J.JCONREL.2010.06.018
John W. Finley, Edward L. Wheeler, Sue C. Witt, Oxidation of glutathione by hydrogen peroxide and other oxidizing agents. Journal of Agricultural and Food Chemistry. ,vol. 29, pp. 404- 407 ,(1981) , 10.1021/JF00104A045
Pieter J. Gaillard, Chantal C. M. Appeldoorn, Rick Dorland, Joan van Kregten, Francesca Manca, Danielle J. Vugts, Bert Windhorst, Guus A. M. S. van Dongen, Helga E. de Vries, David Maussang, Olaf van Tellingen, Pharmacokinetics, Brain Delivery, and Efficacy in Brain Tumor-Bearing Mice of Glutathione Pegylated Liposomal Doxorubicin (2B3-101) PLoS ONE. ,vol. 9, pp. e82331- ,(2014) , 10.1371/JOURNAL.PONE.0082331
Huali Chen, Lei Tang, Yao Qin, Yujia Yin, Jie Tang, Wenwei Tang, Xun Sun, Zhirong Zhang, Ji Liu, Qin He, Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery. European Journal of Pharmaceutical Sciences. ,vol. 40, pp. 94- 102 ,(2010) , 10.1016/J.EJPS.2010.03.007