Nicotiana benthamiana resistance to non‐adapted Melon necrotic spot virus results from an incompatible interaction between virus RNA and translation initiation factor 4E
作者： Cristina Nieto , Luis Rodríguez-Moreno , Ana M. Rodríguez-Hernández , Miguel A. Aranda , Verónica Truniger
DOI: 10.1111/J.1365-313X.2011.04507.X
关键词: RNA virus 、 Translation factor 、 Nicotiana benthamiana 、 Virulence 、 Recombinant virus 、 Virology 、 Virus 、 Melon necrotic spot virus 、 Genetics 、 Viral replication 、 Biology
摘要: Present address: Centro Nacional de Biotecnologia (CNB), Consejo Superior Investigaciones Cientificas (CSIC), 28049 Cantoblanco, Madrid, Spain. SUMMARY Nicotiana benthamiana has been described as non-host for Melon necrotic spot virus (MNSV). We investigated the basis of this resistance using unique opportunity provided by strain MNSV-264, a recombinant that is able to overcome resistance. Analysis chimeric MNSV mutants showed virulence in N. conferred 49 nucleotide section MNSV-264 3¢-UTR, which acts host cap-independent translational enhancer (3¢-CITE). Although 3¢-CITE non-adapted MNSV-Ma5 active susceptible melon, it does not promote efficient translation benthamiana, thus preventing expression proteins required replication. However, gains ability multiply cells if eIF4E from melon variety (Cm-eIF4E-S) supplied trans. These data show results incompatibility between MNSV-Ma 53 ¢-CITE and initiating viral genome. Therefore, inability susceptibility factor support multiplication may be possible mechanism type viruses.
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