Oral contraceptives and venous thromboembolism: A case-control study

摘要: To assess the influence of oral contraceptives (OC) on risk for venous thromboembolism (VTE) in young women, a 5-year case-control study including all women 15-44 years old suffering first deep thrombosis or pulmonary embolism from Danish hospitals, along with 1200 control subjects during period 1994-1995, was conducted. Of 586 patient and subject questionnaires sent out, 523 (89.2%) 1074 (89.5%) were returned an agreement to participate. After exclusion nonvalid diagnoses, who pregnant, previous VTE acute myocardial infarction (AMI), 375 patients 1041 available analysis. Potential tested confounders included: body mass index, length OC use, family history VTE, AMI, stroke, smoking habits, coagulopathies, diabetes, schooling, certainty diagnosis, births, treated hypertension any pregnancy. A multivariate analysis performed. Estrogen dose had no VTE. The among current users primarily influenced by duration significantly decreasing odds ratios (OR) over time: 5 years; 2.1 (1.5-3.1), compared those nonusers OC. This trend still significant after adjustment progestin types. Without second generation (levonorgestrel norgestimate) third (desogestrel gestodene) progestins OR 1.8 (1.1-2.9) 3.2 (2.3-4.4), respectively. correction however, differences found between different types progestins. In conclusion, increase significantly. is use. No difference according estrogen dose, not statistically