Role of microRNAs in Chronic Lymphocytic Leukemia Pathogenesis

摘要: MicroRNAs (miRNAs) are a group of small endogenous non-coding RNAs involved in many cancers and various cellular processes such as growth, DNA methylation, apoptosis, differentiation. 13q14.3 chromosomal region contains miR-15 miR-16 deletion this is commonly reported aberration Chronic Lymphoblastic Leukemia (CLL), suggesting miRNAs involvement CLL pathogenesis. known oncogenes tumor suppressors which may also serve markers onset progression the disease. The most prevalent form leukemia diagnosed adults western world, chronic lymphocytic leukemia, accounts for one-third all leukemias. characterized by presence B Cell Malignant Clones secondary lymphoid tissues, peripheral blood bone marrow. precise etiology remained to be known, however, number Chromosomal Abnormalities deletions 13q14.3, 11q 17p trisomy 12 have been detected. In review, we offer our prospect on how pathogenesis disease progression. Further understanding underlying mechanisms regulation has underscored need further research regarding their role