A taxon-specific and high-throughput method for measuring ligand binding to nicotinic acetylcholine receptors

作者: Christina N Zdenek , Richard J Harris , Sanjaya Kuruppu , Nicholas J Youngman , James S Dobson

DOI: 10.3390/TOXINS11100600

关键词: MimotopeAcetylcholine receptorBiologyNicotinic agonistLigand (biochemistry)Nicotinic acetylcholine receptorLineage (evolution)Generalist and specialist speciesVenomComputational biology

摘要: … In addition, this study investigates the usefulness of this method for biodiscovery by testing for ligands that selectively bind to the full range of human α-nAChR subunits. This tool, …

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