Effects of Lespedeza Bicolor Extract on Regulation of AMPK Associated Hepatic Lipid Metabolism in Type 2 Diabetic Mice.

摘要: Lespedeza bicolor (LB) is one of the ornamental plants used for treatment inflammation caused by oxidative damage. However, its beneficial effects on hyperglycemia-induced hepatic damage and related molecular mechanisms remain unclear. We hypothesized that extract (LBE) would attenuate liver injury in type 2 diabetes mellitus (T2DM). Diabetes was induced a low dosage streptozotocin (STZ) injection (30 mg/kg) with high fat diet male C57BL/6J mice. LBE administered orally at 100 mg/kg or 250 12 weeks. supplementation regardless ameliorated plasma levels hemoglobin A1c (HbA1c) diabetic Moreover, both supplementations upregulated AMP-activation kinase (AMPK), which may activate sirtuin1 (SIRT) associated pathway accompanied decreased lipid synthesis dose supplementation. These changes were part explained reduced protein stress (nuclear factor erythroid 2-related (Nrf2) catalase), kappa B (NF-κB), interleukin-1β (IL-1β), interleukin-6 (IL-6), nitric oxide synthases (iNOS)), fibrosis (α-smooth muscle actin (α-SMA) C (PKC)) liver. Taken together, might be potential nutraceutical to ameliorate regulation AMPK via stress, inflammation, T2DM.