Protective and pathological roles of nitric oxide in endotoxin shock

作者： C. E Wright , D. D Rees , S. Moncada

关键词: Anesthesia 、 Mean arterial pressure 、 Nitric oxide 、 Medicine 、 Omega-N-Methylarginine 、 Pharmacology 、 Vasoconstriction 、 Shock (circulatory) 、 Dexamethasone 、 Lipopolysaccharide 、 Nitric oxide synthase

摘要: Objective: The aim was to investigate the effects of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of both the constitutive (Ca2+ dependent) and inducible (Ca2+ independent) nitric oxide (NO) synthases, or of pretreatment with the glucocorticoid dexamethasone, an inhibitor of the induction of the Ca2+ independent NO synthase, on lipopolysaccharide induced shock in the anaesthetised rabbit. Methods: Mean arterial blood pressure, and blood flow in the portal vein, hepatic artery, and hindquarter vascular beds were measured …