FDG-PET in Cervical Cancer - Translational Studies

摘要: Cervical cancer is the second most common in females. The treatment, based on clinical FIGO stage, carries a significant risk of side effects. FDG-PET enables non-invasive studies glucose metabolism. Cancer cells show an increased uptake and metabolism that can be visualised further analysed. The aims this thesis were to evaluate management cervical experimentally investigate metabolic changes tumour following cytotoxic treatment. In prospective study we found provided important information about extent disease primary staging locally advanced cases re-staging recurrent disease. treatment plans altered as result findings for one fourth patients. Surveillance 6 months after surgery early-stage showed no value. With predictive early during radiotherapy could identify group patients with excellent prognosis. However, majority prediction outcome was not possible. Persisting hypermetabolism 3 completed associated relapse. Experimentally, transient flare xenografted tumours day 1 cisplatin exposure. A squamous cell carcinoma vitro sign response No increase detected fibroblasts or reactive vivo. In conclusion, have demonstrated value cancer, experimental setting understanding