Acute withdrawal-related hypophagia elicited by amphetamine is attenuated by pretreatment with selective dopamine D1 or D2 receptor antagonists in rats.

摘要: After receiving 2.0mg/kg amphetamine, rats show two phases of reduced food intake, short-term hypophagia, during the first several hours after treatment, and longer-term approximately 19 to 26 h treatment. The hypophagia may be an indicator acute withdrawal. This study assessed whether D1 D2 receptor activation were important early events in elicitation hypophagia. Throughout a series five-day tests, could lever press for pellets one-hour periods beginning every 3h. On test day 1, given saline pretreatment, 15 min later they 3, pretreatment either or selective dopamine antagonist, treatment amphetamine (2.0mg/kg). In Experiment pretreatments included 12, 31, 50 μg/kg antagonist SCH 23390. 2, 25, 50, 100 eticlopride. Distance moved was monitored 6h following pretreatment-treatment combinations obtain indirect behavioral measure blockade (antagonist attenuation hyperactivity). Food intake at each meal opportunity throughout five test. Patterns 1 saline-saline 3 compared. combination saline-amphetamine produced Combinations involving antagonist-saline did not produce changes intake. Pretreatment with 12 23390 substantial hyperactivity prevented amphetamine-induced acute-withdrawal-related Eticlopride partial Both are required full expression administration.