Pilot study of early repeated 18F-FDG PET during cycle 1 to predict objective response to chemotherapy in advanced non-small cell lung cancer (NSCLC)

摘要: 8003 Background: FDG-PET already showed to be an early assessment of anticancer treatment effectiveness in different solid tumours after the first cycle chemotherapy. Aim this pilot study patients (pts) with advanced NSCLC was test if a second 18F-FDG PET repeated two weeks start chemotherapy is predictive subsequent response and survival. Patients Methods: Twenty pts clinical stage IIIB (n=1) or IV (n=21) receiving front line platinum-based within trial were consecutively prospectively enrolled. Male/female ratio 18/4, adenocarcinoma 11, squamous 6, NSCLC-NOS 5. All underwent scan at baseline (PET1), 15 days beginning (PET2) end Assessment disease by spiral CT chest abdomen performed every other cycle. Tumour evaluated according RECIST criteria analysis scans (including % change standardized uptake...