Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
作者： Paula I. Moreira , Cristina Carvalho , Xiongwei Zhu , Mark A. Smith , George Perry
DOI: 10.1016/J.BBADIS.2009.10.006
关键词: Autophagy 、 Lipofuscin 、 Oxidative stress 、 Biology 、 Protein aggregation 、 Mitochondrion 、 Programmed cell death 、 Pathogenesis 、 Cell biology 、 Disease
摘要: … Alzheimer's disease. This review discusses evidence indicating that mitochondrial dysfunction has an early and preponderant role in Alzheimer's disease. Furthermore, the link between …
core.ac.uk
archives-ouvertes.fr
elsevier.com
saludmitocondrial.net 参考文章(77)
Ralph A. Nixon, Jerzy Wegiel, Asok Kumar, Wai Haung Yu, Corrinne Peterhoff, Anne Cataldo, Ana Maria Cuervo, Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. Journal of Neuropathology and Experimental Neurology. ,vol. 64, pp. 113- 122 ,(2005) , 10.1093/JNEN/64.2.113
Paula I. Moreira, Peggy L.R. Harris, Xiongwei Zhu, Maria S. Santos, Catarina R. Oliveira, Mark A. Smith, George Perry, Lipoic Acid and N-acetyl Cysteine Decrease Mitochondrial-Related Oxidative Stress in Alzheimer Disease Patient Fibroblasts Journal of Alzheimer's Disease. ,vol. 12, pp. 195- 206 ,(2007) , 10.3233/JAD-2007-12210
Paula I. Moreira, Ana I. Duarte, Maria S. Santos, A. Cristina Rego, Catarina R. Oliveira, An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease. Journal of Alzheimer's Disease. ,vol. 16, pp. 741- 761 ,(2009) , 10.3233/JAD-2009-0972
Akihiko Nunomura, George Perry, Gjumrakch Aliev, Keisuke Hirai, Atsushi Takeda, Elizabeth K. Balraj, Paul K. Jones, Hossein Ghanbari, Takafumi Wataya, Shun Shimohama, Shigeru Chiba, Craig S. Atwood, Robert B. Petersen, Mark A. Smith, Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. ,vol. 60, pp. 759- 767 ,(2001) , 10.1093/JNEN/60.8.759
Gemma Casadesus, Mark A. Smith, Samar Basu, Jing Hua, Dae E. Capobianco, Sandra L. Siedlak, Xiongwei Zhu, George Perry, Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. Molecular Neurodegeneration. ,vol. 2, pp. 2- 2 ,(2007) , 10.1186/1750-1326-2-2
Paula I. Moreira, Maria S. Santos, António Moreno, Catarina Oliveira, Amyloid β-Peptide Promotes Permeability Transition Pore in Brain Mitochondria Bioscience Reports. ,vol. 21, pp. 789- 800 ,(2001) , 10.1023/A:1015536808304
Michael O. Hengartner, The biochemistry of apoptosis Nature. ,vol. 407, pp. 770- 776 ,(2000) , 10.1038/35037710
Paula I. Moreira, Maria S. Santos, Cristina Sena, Raquel Seiça, Catarina R. Oliveira, Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats Neurobiology of Disease. ,vol. 18, pp. 628- 637 ,(2005) , 10.1016/J.NBD.2004.10.017
Paula I. Moreira, Sandra L. Siedlak, Xinglong Wang, Maria S. Santos, Catarina R. Oliveira, Massimo Tabaton, Akihiko Nunomura, Luke I. Szweda, Gjumrakch Aliev, Mark A. Smith, Xiongwei Zhu, George Perry, Erratum: Increased autophagic degradation of mitochondria in Alzheimer disease (Autophagy) Autophagy. ,vol. 3, pp. 614- 615 ,(2007) , 10.4161/AUTO.4872
Ruth Tal, Gal Winter, Nitai Ecker, Daniel J. Klionsky, Hagai Abeliovich, Aup1p, a Yeast Mitochondrial Protein Phosphatase Homolog, Is Required for Efficient Stationary Phase Mitophagy and Cell Survival Journal of Biological Chemistry. ,vol. 282, pp. 5617- 5624 ,(2007) , 10.1074/JBC.M605940200