Effects of Genetic Polymorphisms of CYP2D6, CYP3A5, and ABCB1 on the Steady-State Plasma Concentrations of Aripiprazole and Its Active Metabolite, Dehydroaripiprazole, in Japanese Patients With Schizophrenia
作者： Takeshi Suzuki , Kazuo Mihara , Akifumi Nakamura , Shoko Kagawa , Goyo Nagai
DOI: 10.1097/FTD.0000000000000070
关键词: Flunitrazepam 、 Schizophrenia 、 Pharmacology 、 Active metabolite 、 CYP3A5 、 Polymorphism (computer science) 、 Aripiprazole 、 CYP2D6 、 Biperiden 、 Medicine 、 Pharmacology (medical)
摘要: Background We studied the effects of various factors, including genetic polymorphisms cytochrome P450 (CYP) 2D6, CYP3A5, and ABCB1, age, gender, smoking habit on steady-state plasma concentrations aripiprazole its active metabolite, dehydroaripiprazole, in 89 patients with schizophrenia (46 males, 43 females). Methods All had been receiving fixed doses for at least 2 weeks. The daily were 24 mg (n = 56) 12 33). No other drugs except biperiden flunitrazepam coadministered. Plasma dehydroaripiprazole measured using liquid chromatography mass-spectrometric detection. CYP2D6 (CYP2D6*5, CYP2D6*10, CYP2D6*14), CYP3A5 (CYP3A5*3), ABCB1 (C3435T G2677T/A) genotypes identified by PCR analyses. Results mean concentration/dose ratios sum significantly higher 1 (P Conclusions findings this study suggest that play an important role controlling Asian subjects, whereas seemed unlikely to have impact.
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