Clinical utility of a non-invasive urine test for risk assessing patients with no obvious benign cause of hematuria: a physician-patient real world data analysis

作者: Tony Lough , Qingyang Luo , Carthika Luxmanan , Alastair Anderson , Jimmy Suttie

DOI: 10.1186/S12894-018-0327-6

关键词: ReferralTest (assessment)TriageEmergency medicineRisk assessmentModalitiesCystoscopyBiomarker (medicine)Lower riskMedicine

摘要: The non-invasive Cxbladder urine test system has demonstrated clinical utility in ruling out urothelial carcinoma (UC) patients with asymptomatic microscopic hematuria (AMH), suggesting that the number of invasive diagnostic tests, including cystoscopy, used this patient population may be reduced by testing prior to conducting a full urological work-up. aim study was demonstrate enhanced communicating objective information on decisions made individual physicians AMH. Three hundred ninety-six physician-patient were generated from twelve participant evaluating real world case notes same 33 presenting Each physician reviewed and recommended tests procedures based each patient’s referral data then re-evaluated their recommendation following disclosure result. Changes assessed were the total requested procedures, addition Triage Detect modalities. Physicians significant changes behavior for AMH when presented results, reduction cystoscopy individuals identified as having low probability UC. intensity investigation targeted increased, use high UC: urologists increased level for both procedures. outcome resulted risk UC receiving appropriate guideline-recommended tests. Patients who tested negative offered fewer significantly less This change results an utility, lower missed test-related harm incidents. potential resolution management, consider evaluation. led more procedure selection resource allocation benefit both healthcare systems.

参考文章(32)
Leslee L. Subak, Deborah Grady, Asymptomatic Microscopic Hematuria-Rethinking the Diagnostic Algorithm. JAMA Internal Medicine. ,vol. 177, pp. 808- 809 ,(2017) , 10.1001/JAMAINTERNMED.2017.0758
Brian Ngo, Nathan Papa, Marlon Perera, Damien Bolton, Shomik Sengupta, Predictors of delay to cystoscopy and adequacy of investigations in patients with haematuria BJUI. ,vol. 119, pp. 19- 25 ,(2017) , 10.1111/BJU.13809
Jacob T. Ark, JoAnn R. Alvarez, Tatsuki Koyama, Jeffrey C. Bassett, William J. Blot, Michael T. Mumma, Matthew J. Resnick, Chaochen You, David F. Penson, Daniel A. Barocas, Variation in the Diagnostic Evaluation among Persons with Hematuria: Influence of Gender, Race and Risk Factors for Bladder Cancer Journal of Urology. ,vol. 198, pp. 1033- 1038 ,(2017) , 10.1016/J.JURO.2017.06.083
Steve P. McCombie, Haider K. Bangash, Melvyn Kuan, Isaac Thyer, Fran Lee, Dickon Hayne, Delays in the diagnosis and initial treatment of bladder cancer in Western Australia BJUI. ,vol. 120, pp. 28- 34 ,(2017) , 10.1111/BJU.13939
Yoram I. Siegel, Arie Lindner, Kobi Stav, Dan Leibovici, Amnon Zisman, Elyahu Goren, Anna Livshitz, Adverse effects of cystoscopy and its impact on patients' quality of life and sexual performance. Israel Medical Association Journal. ,vol. 6, pp. 474- 478 ,(2004)
D.M. Burke, D.C. Shackley, P.H. O'Reilly, The community‐based morbidity of flexible cystoscopy BJUI. ,vol. 89, pp. 347- 349 ,(2002) , 10.1046/J.1464-4096.2001.01899.X
Joshua A. Cohn, Benjamin Vekhter, Christopher Lyttle, Gary D. Steinberg, Michael C. Large, Sex disparities in diagnosis of bladder cancer after initial presentation with hematuria: a nationwide claims-based investigation. Cancer. ,vol. 120, pp. 555- 561 ,(2014) , 10.1002/CNCR.28416
Bishoy A Gayed, Jessica Gillen, Alana Christie, Samuel Peña-Llopis, Xian-Jin Xie, Jingsheng Yan, Jose A Karam, Ganesh Raj, Arthur I Sagalowsky, Yair Lotan, Vitaly Margulis, James Brugarolas, Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma. BMC Urology. ,vol. 15, pp. 1- 8 ,(2015) , 10.1186/S12894-015-0019-4
Hyuk Sang Jung, Dong Kyun Park, Min Ju Kim, Sang Kyun Yu, Kwang An Kwon, Yang Suh Ku, Yu Kyung Kim, Ju Hyun Kim, EGFR and KRAS Mutations in Patients With Adenocarcinoma of the Lung The Korean Journal of Internal Medicine. ,vol. 24, pp. 48- 54 ,(2009) , 10.3904/KJIM.2009.24.1.43
Rodney Davis, J. Stephen Jones, Daniel A. Barocas, Erik P. Castle, Erich K. Lang, Raymond J. Leveillee, Edward M. Messing, Scott D. Miller, Andrew C. Peterson, Thomas M.T. Turk, William Weitzel, Diagnosis, Evaluation and Follow-Up of Asymptomatic Microhematuria (AMH) in Adults: AUA Guideline The Journal of Urology. ,vol. 188, pp. 2473- 2481 ,(2012) , 10.1016/J.JURO.2012.09.078