A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo
作者： C Eberlein , J Kendrew , K McDaid , A Alfred , J S Kang
DOI: 10.1038/ONC.2012.460
关键词: In vitro 、 Biology 、 Integrin 、 Molecular biology 、 Metastasis 、 In vivo 、 Monoclonal antibody 、 Cancer research 、 Transforming growth factor 、 Matrigel Invasion Assay 、 Fibronectin
摘要: Abstract αvβ6 integrin expression is upregulated on a wide range of epithelial tumours, and is thought to play a role in modulating tumour growth. Here we describe a human therapeutic antibody 264RAD, which binds and inhibits αvβ6 integrin function. 264RAD cross-reacts with human, mouse and cynomolgus monkey αvβ6, and inhibits binding to all ligands including the latency-associated peptide of TGF-β. Screening across a range of integrins revealed that 264RAD also binds and inhibits the related integrin αvβ8, but not the …
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