Metabolism and molecular systems for the biotransformation of aromatic molecules. Annual Project Meeting: Naples, 19 January 2010

摘要: The collection of papers is the result first year's results Project: METABOLISM AND MOLECULAR SYSTEMS FOR THE BIOTRANSFORMATION OF AROMATIC MOLECULES. Aim research project to gain knowledge in microorganisms endowed with ability transforming aromatic compounds, and genes enzymes involved this process. Particular attention paid information acquired for its use development biosynthetic systems bioremediation and bioconversions. The pathways responsible aerobic catabolism molecules are generally made up an upper pathway, where hydroxylation reactions leading the formation hydroxylated intermediates occur, a lower pathway ring these dihydroxylated cleaved, eventually converted, after several enzymatic steps, into Krebs cycle. It goes without saying that great potential related the acquisition about involved regulation their corresponding genes. utilization micro-organisms can be expanded improved by: (i) characterizing new sort out wide panel different metabolic abilities different specificity, (ii) elucidating transcriptional molecular determinants activities already known those will be available during project. Moreover, order evaluate influence gained developing processes it necessary (iii) validate small number applications. More specifically goals have been achieved through: 1) Isolation characterization bacterial strains either by isolation from polluted sites or spotting ones through analysis annotated genomes for identifying both enhanced catalytic biodegradative properties; 2) identification specificity which project; 3) investigation transcription regulative expression (in particular key enzymes metabolism aromatic compounds) psychrophilic mesophilic bacteria; 4) obtained approaches above set-up biocatalysts model wastewaters the biosynthesis compounds pharmaceutical industrial interest.