ctDNA-based mutational landscape following anti-EGFR antibodies in metastatic colorectal cancer (mCRC) to uncover novel resistance mechanisms in the CCTG CO.26 trial.
作者： Harriet Feilotter , Derek Jonker , Kimberly Banks , Christopher J. O'Callaghan , Dongsheng Tu
DOI: 10.1200/JCO.2021.39.3_SUPPL.117
关键词: Protein kinase B 、 Antibody 、 MAPK/ERK pathway 、 Medicine 、 Colorectal cancer 、 Acquired resistance 、 Cancer research 、 PI3K/AKT/mTOR pathway
摘要: 117Background: Previous studies have identified MAPK and PIK3CA/AKT/mTOR pathways as common mechanisms of acquired resistance to anti-EGFR antibodies (EGFRab) in mCRC. However, such alterations do ...
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