Staphylococcal bacteraemia, fusidic acid, and jaundice.

摘要: Fusidic acid was used to treat 131 out of 250 patients with staphylococcal bacteraemia over 10 years. Other antimicrobial agents were given the 119 remaining patients. Thirty-seven already jaundiced before antibiotic treatment started. Jaundice developed during in 38 112 fusidic (34%) and two 101 other antimicrobials. The incidence jaundice higher intravenously (48%) rather than by mouth (13%). appeared within 48 hours after administration 93% these cases. When drug stopped serum bilirubin concentrations fell normal values four days those whom they had been previously who survived bacteraemic episode. associated increasing 13 19 (68%) it given. In six 32 while receiving intravenous alkaline phosphatase activity raised suggestive cholestatic jaundice. mechanism unknown. acid, particularly preparation, invaluable treating severe infection but should be caution abnormal liver function. Patients oral form as soon their clinical condition permits.