Thymosins: structure, function and therapeutic applications

摘要: Using a partially purified preparation, thymosin fraction 5, we have documented that can correct many of the immunological deficiencies resulting from lack function in animal models and humans. Ongoing studies indicate there is family biologically active peptides within 5 act on T-cell subpopulations to maintain normal reactivity. Several these been homogeneity. Two peptides, alpha 1 beta 4, sequenced chemically synthesized. Thymosin has used most clinical trials reported date, including children with immunodeficiency disease patients autoimmune diseases cancer. Most recently, National Cancer Institute initiated number Phase I II synthetic as part new Biological Response Modifier Program. Preliminary results two look encouraging.