Methods for the preparation and formulation of l-carnitine valproate salts
作者： Navdeep Balkrishna Malkar , Deanna Jean Nelson
DOI:
关键词: Pharmacology 、 Carnitine 、 Medicine
摘要: The present invention relates to methods for preparing an L-carnitine valproate salt and administering this compound a subject in need of treatment with valproate. Pharmaceutical compositions are also provided that useful therapies the neurological, immunological, viral-mediated disorders warm-blooded mammals.
google.nl 参考文章(3)
Hans Dipl Chem Dr Dietl, L-Carnitine derivatives of valproic acid and pharmaceuticals containing these ,(1987)
Claudio Cavazza, Use of L-carnitine or acyl L-carnitines and valproate for treating seizure disorders ,(1994)
Taishi Takeuchi, Tateo Sugimoto, Naoki Nishida, Yohnosuke Kobayashi, Protective effect of D-L-carnitine on valproate-induced hyperammonemia and hypoketonemia in primary cultured rat hepatocytes Biochemical Pharmacology. ,vol. 37, pp. 2255- 2258 ,(1988) , 10.1016/0006-2952(88)90589-8