Uniaxial loading induces a scalable switch in cortical actomyosin flow polarization and reveals mechanosensitive regulation of cytokinesis

摘要: Abstract During animal development, it is crucial that cells can sense and adapt to mechanical forces from their environment. Ultimately, these are transduced through the actomyosin cortex. How cortex simultaneously respond create during cytokinesis not well understood. Here we show under stress, cortical flow switches its polarization in C. elegans embryo. In unstressed embryos, longitudinal flows contribute contractile ring formation, while rotational additionally induced uniaxially loaded embryos. Rotational required for redistribution of Rupture longitudinally aligned fibers rotation releases tension, initiates orthogonal thereby contributes furrowing A targeted screen factors revealed regulators involved RhoA regulation, polarity chirality all become essential stress. sum, our findings extend current framework stress response cell division scaling amount