Decreased keratinocyte motility in skin wound on mice lacking the epidermal fatty acid binding protein gene.

摘要: Fatty acids are shown to be important in various skin functions. acid binding protein (FABP) is postulated serve as a lipid shuttle, solubilizing hydrophobic fatty and delivering them the appropriate metabolic system. Among FABP family proteins, epidermal-type (E-FABP) solely expressed keratinocyte but its specific role not yet fully established. We found an elevated expression of E-FABP regenerative keratinocytes healing wounds. However, null mice showed no marked differences compared wild type process wound closure, vivo. On other hand, culture, gene disruption decreased cell motility, did affect proliferation. deletion may compensated for vivo by microenvironment comprised cells such fibroblasts endothelial around wound. Our analyses suggest that elevation necessary activation motility within epidermis during healing.