Catalytic, Asymmetric Michael Reactions of Cyclic Diketones with β,γ-Unsaturated-α-ketoesters
作者： Michael A. Calter , Jun Wang
DOI: 10.1021/OL900586F
关键词: Michael reaction 、 Cinchona Alkaloids 、 Catalysis 、 Alkyl 、 Stereoisomerism 、 Cinchona 、 Organic chemistry 、 Chemistry 、 Aryl 、 Electrophile
摘要: Newly synthesized cinchona alkaloid-derived pyrimidines function as effective asymmetric catalysts for the Michael reaction between cyclic diketones and β,γ-unsaturated α-ketoesters. The reactions of electrophiles with either aryl or alkyl γ-substituents give 64−99% yields 94−99% ee.
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