Dysbiosis caused by vitamin D receptor deficiency confers colonization resistance to Citrobacter rodentium through modulation of innate lymphoid cells.
作者： J Chen , A Waddell , Y-D Lin , M T Cantorna
DOI: 10.1038/MI.2014.94
关键词: Innate lymphoid cell 、 Microbiology 、 Receptor 、 Citrobacter rodentium 、 Dysbiosis 、 Calcitriol receptor 、 Colonisation resistance 、 Transplantation 、 Biology 、 Gut flora
摘要: Vitamin D receptor (VDR) knockout (KO) mice had fewer Citrobacter rodentium in the feces than wild-type (WT) and kinetics of clearance was faster VDR KO WT mice. more interleukin-22 (IL-22)-producing innate lymphoid cells (ILCs) antibacterial peptides The increased ILCs a cell-autonomous effect deficiency on ILC frequencies. Bone marrow (BM) transplantation from into resulted higher colonization resistance Disruption gut microbiota using antibiotics reversed to C. infection. Confirming role mice, transfer germ-free resistance. Once overcome, susceptibility rodentium. expression is regulator frequencies, IL-22, dysbiosis, susceptibility.
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Shaoping Wu, Anne P. Liao, Yinglin Xia, Yan Chun Li, Jian-Dong Li, R. Balfour Sartor, Jun Sun, Vitamin D receptor negatively regulates bacterial-stimulated NF-κB activity in intestine American Journal of Pathology. ,vol. 177, pp. 686- 697 ,(2010) , 10.2353/AJPATH.2010.090998
Sanhong Yu, Margherita T. Cantorna, The vitamin D receptor is required for iNKT cell development. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 5207- 5212 ,(2008) , 10.1073/PNAS.0711558105
Steven A. Luperchio, David B. Schauer, Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia. Microbes and Infection. ,vol. 3, pp. 333- 340 ,(2001) , 10.1016/S1286-4579(01)01387-9
Christopher G. Mayne, Justin A. Spanier, Lance M. Relland, Calvin B. Williams, Colleen E. Hayes, 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis European Journal of Immunology. ,vol. 41, pp. 822- 832 ,(2011) , 10.1002/EJI.201040632
N. Kamada, Y.-G. Kim, H. P. Sham, B. A. Vallance, J. L. Puente, E. C. Martens, G. Nunez, Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science. ,vol. 336, pp. 1325- 1329 ,(2012) , 10.1126/SCIENCE.1222195
Nawal Salahuddin, Farheen Ali, Zahra Hasan, Nisar Rao, Masooma Aqeel, Faisal Mahmood, Vitamin D accelerates clinical recovery from tuberculosis: results of the SUCCINCT Study [Supplementary Cholecalciferol in recovery from tuberculosis]. A randomized, placebo-controlled, clinical trial of vitamin D supplementation in patients with pulmonary tuberculosis’ BMC Infectious Diseases. ,vol. 13, pp. 22- 22 ,(2013) , 10.1186/1471-2334-13-22
Christian Wejse, Victor F. Gomes, Paulo Rabna, Per Gustafson, Peter Aaby, Ida M. Lisse, Paul L. Andersen, Henning Glerup, Morten Sodemann, Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial. American Journal of Respiratory and Critical Care Medicine. ,vol. 179, pp. 843- 850 ,(2009) , 10.1164/RCCM.200804-567OC
J. Wesley Pike, Mark B. Meyer, The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3 Endocrinology and Metabolism Clinics of North America. ,vol. 39, pp. 255- 269 ,(2010) , 10.1016/J.ECL.2010.02.007
Christian M. Veldman, Margherita T. Cantorna, Hector F. DeLuca, Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System☆ Archives of Biochemistry and Biophysics. ,vol. 374, pp. 334- 338 ,(2000) , 10.1006/ABBI.1999.1605
Stephen J. Rubino, Kaoru Geddes, Stephen E. Girardin, Innate IL-17 and IL-22 responses to enteric bacterial pathogens Trends in Immunology. ,vol. 33, pp. 112- 118 ,(2012) , 10.1016/J.IT.2012.01.003