Do the expressions of epithelial–mesenchymal transition proteins, periostin, integrin-α4 and fibronectin correlate with clinico-pathological features and prognosis of metastatic castration-resistant prostate cancer?:

摘要: Development of metastatic castration-resistant prostate cancer is a result the lack an apoptotic response by tumor cells and loss ability to stick adjacent through epithelial-mesenchymal transition. Although there are several strongly recommended biomarkers for determining prognosis cancer, only few them may help decide selection optimal treatment option. The mode sequencing in will be based on individual characteristics patient. In this study, we aimed explain correlation between expression periostin, integrin-α4, fibronectin patients their clinico-pathological data comprising Gleason score, PSA levels, sites process We evaluated using Western blotting, expressions peripheral blood samples ( n = 40), benign prostatic hyperplasia n = 20), healthy control group n = 20). Associations changes protein parameters were also analyzed group. When comparing BPH groups with group, reduced integrin-α4 was found patients, albeit being statistically insignificant P > 0.05). Protein periostin higher than those heathy P < 0.001). Increased significantly associated bone metastasis P < 0.05). Elevated levels appropriate targets therapeutic intervention future. Impact statement Prostate third most common world among men. (mCRPC) transition (EMT). present study analyzes first time EMT marker proteins - integrin α4, mCRPC (BPH) aim determine clinical relevance these three vis-a-vis PCa aggressive phenotype. doing so, it sheds light molecular mechanism underlying disease. concluded that elevated future; hence, adopting methods target treat effectively.