Effects of Ebselen (PZ 51) on Ischaemic Brain Oedema After Focal Ischaemia in Cats
作者： H. Johshita , T. Sasaki , T. Matsui , T. Hanamura , H. Masayasu
DOI: 10.1007/978-3-7091-9115-6_80
关键词: Medicine 、 Transorbital 、 Ebselen 、 Middle cerebral artery 、 Anesthesia 、 Perfusion 、 CATS 、 Cerebral blood flow 、 Occlusion 、 Ischemia
摘要: Using a transorbital middle cerebral artery (MCA) occlusion model in cats, we evaluated the anti-oedema effects of new anti-inflammatory agent, ebselen (PZ 51), on ischaemic cortical oedema caused by prolonged ischaemia and recirculation. Local blood flow was measured hydrogen clearance method MCA territory corresponding specific gravity assessed microgravimetric technique. Ebselen had no significant effect normal lCBF, while it significantly ameliorated post-ischaemic hypoperfusion following In severely regions, microgravimetry showed beneficial recirculation as well. Although exact site action is undetermined this study, observed may be ascribed to agent’s broad-spectrum activities.
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