Nematicidal Cardenolides from Nerium indicum Mill.

作者: Xing-Biao Wang , Guo-Hong Li , Li-Jun Zheng , Kai-Yan Ji , Hua Lü

DOI: 10.1002/CBDV.200800011

关键词: Nerium indicumUzarigeninPlant compositionPesticidePanagrellus redivivusFractionationChemistryTraditional medicineCardenolideEnvironmental chemistryBursaphelenchus xylophilus

摘要: Three nematicidal cardenolides were obtained from the AcOEt extract of Nerium indicum Mill. by bioassay-guided fractionation. They include a new compound, 3beta-O-(beta-D-diginosyl)-14,15alpha-dihydroxy-5alpha-card-20(22)-enolide (1), and two known compounds, uzarigenin (2) cardenolide N-1 (3). The median lethal concentrations (LC(50)) compounds 1-3 against nematodes Bursaphelenchus xylophilus, Panagrellus redivivus, Caenorhabditis elegans at 72 h 103.3, 49.0, 45.4 mg l(-1), 257.0, 62.7, 177.8 242.9, 29.1, 41.7 respectively. This is first report about activity cardenolides.

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