作者: Xing-Biao Wang , Guo-Hong Li , Li-Jun Zheng , Kai-Yan Ji , Hua Lü
关键词: Nerium indicum 、 Uzarigenin 、 Plant composition 、 Pesticide 、 Panagrellus redivivus 、 Fractionation 、 Chemistry 、 Traditional medicine 、 Cardenolide 、 Environmental chemistry 、 Bursaphelenchus xylophilus
摘要: Three nematicidal cardenolides were obtained from the AcOEt extract of Nerium indicum Mill. by bioassay-guided fractionation. They include a new compound, 3beta-O-(beta-D-diginosyl)-14,15alpha-dihydroxy-5alpha-card-20(22)-enolide (1), and two known compounds, uzarigenin (2) cardenolide N-1 (3). The median lethal concentrations (LC(50)) compounds 1-3 against nematodes Bursaphelenchus xylophilus, Panagrellus redivivus, Caenorhabditis elegans at 72 h 103.3, 49.0, 45.4 mg l(-1), 257.0, 62.7, 177.8 242.9, 29.1, 41.7 respectively. This is first report about activity cardenolides.