The significance of anterior prostate lesions on multiparametric magnetic resonance imaging in African-American men

摘要: Abstract Introduction African-American (AA) men tend to harbor high-risk prostate cancer (PCa) and exhibit worse outcomes when compared other groups. It has been postulated that AA may more anterior lesions (APLs) are undersampled by the standard transrectal ultrasound guided-biopsy (SBx), potentially resulting in greater degree of Gleason score (GS) upgrading at radical prostatectomy. We aimed evaluate detection rate PCa significance APLs on multiparametric magnetic resonance imaging (mpMRI) compare it a matched cohort White/Other (W/O) men. Materials methods A review 1,267 who had an mpMRI with suspicious underwent fusion-guided biopsy (FBx) concurrent SBx same session was performed. All were control group W/O using 1:1 propensity score-matching algorithm age, prostate-specific antigen, volume as matching variables. Logistic regression analysis used determine predictors Results Of 195 mpMRI, 93 (47.7%) total 109 APLs. Prior negative associated presence (Odds ratio = 1.81; 95% CI: 1.03–3.20; P 0.04). On multivariate logistic analysis, smaller (P 0.001) rising antigen 0.007) independent cancer-positive Comparative (93/195, 47.7%) vs. (100/194, 52%) showed no difference rates 0.44) or within those distribution GS cancers 0.63) despite overall higher (AA: 124/195 [63.6%] W/O: 97/194 [50.0%], 0.007). In cases where positive for FBx, APL equal highest entire gland 82.9% (29/35) 90.9% (30/33) time men, respectively. Conclusion Cancer-positive represented risk most cases. prior twice likely concerning APL. our cohort, comparable mpMRI. Thus, differences do not explain deahth due PCa. However, targeting via FBx can clinically improve stratification guide appropriate treatment options.