A New UK 2006 National Kidney Allocation Scheme for deceased heart-beating donor kidneys.

摘要: Introduction. In 2004, it was agreed that a new allocation scheme for kidneys from deceased heart-beating donors required in the United Kingdom to address observed inequities access transplant. The 2006 National Kidney Allocation Scheme (2006 NKAS) developed meet objectives and preparatory work included review of criteria human leukocyte antigen (HLA) matching simulation evidence about effectiveness alternative schemes. Algorithm NKAS. NKAS gives absolute priority all 000 HLA-A, -B, -DR-mismatched patients well-matched pediatric (<18 years), then points score defines priorities with waiting time being most influential. Points age HLA mismatch are linked novel approach ensure transplants younger while recognizing is less important older as retransplantation likely be required. To improve equity difficult match patients, rare specificities were defaulted more common, related specificities. Impact After 3 years, already making good progress achieving its objectives, overall results similar those simulations. There has been significant benefit than 5 years A number other advantages also apparent improving many respects, including achievement transplant HLA-DR homozygous but geographical inequity will take fully.