Precursor T-Cell Neoplasms

作者: Kim De Keersmaecker , Adolfo Ferrando

DOI: 10.1007/978-1-4419-5698-9_26

关键词: Acute lymphoblastic leukemiasMinimal residual diseaseMediastinal massFusion transcriptNotch1 signalingBone marrowMedicineT cellPathology

摘要: Precursor T-cell lymphoblastic leukemias and lymphomas represent 15% of childhood acute (ALLs) one third pediatric non-Hodgkin lymphomas, respectively. ALLs are characterized by prominent (>30%) bone marrow (BM) infiltration with or without mediastinal mass, while show masses in the context limited no BM involvement. These two clinical entities share a similar spectrum molecular cytogenetic abnormalities, most probably different manifestations same disease, commonly designated here as T-ALL.

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