作者: Kim De Keersmaecker , Adolfo Ferrando
DOI: 10.1007/978-1-4419-5698-9_26
关键词: Acute lymphoblastic leukemias 、 Minimal residual disease 、 Mediastinal mass 、 Fusion transcript 、 Notch1 signaling 、 Bone marrow 、 Medicine 、 T cell 、 Pathology
摘要: Precursor T-cell lymphoblastic leukemias and lymphomas represent 15% of childhood acute (ALLs) one third pediatric non-Hodgkin lymphomas, respectively. ALLs are characterized by prominent (>30%) bone marrow (BM) infiltration with or without mediastinal mass, while show masses in the context limited no BM involvement. These two clinical entities share a similar spectrum molecular cytogenetic abnormalities, most probably different manifestations same disease, commonly designated here as T-ALL.